Central neurotransmitters and control of prolactin secretion

نویسندگان

  • C. KORDON
  • A. ENJALBERT
چکیده

Despite extensive study during the last 10 years, several aspects of the neural control of prolactin secretion are still unelucidated. In mammals, the most important feature of this control is the existence of a predominant inhibitory regulation, as demonstrated by a number of older experiments involving hypothalamo-hypophyseal deconnexion, interruption of the portal circulation, ectopic grafts of the pituitary, as well as in vitro incubations of adenohypophyseal tissue (see review in Meites and Nicoll, 1966 and Pasteels, 1967). Under all these conditions, elimination of hypothalamic influences induces a remarkable stimulation of prolactin secretion. This powerful repressor effect of the hypothalamus often masked more limited stimulatory effects, which, nevertheless, can be expressed under certain physiological or experimental conditions. In other species like birds (Kragt and Meites, 1965 ; Gourdji and TixierVidal, 1966), such stimulatory effects even appear more important than the inhibitory component of the regulation. The complexity of mechanisms regulating prolactin release reflects the large variety of physiological situations in which changes in prolactin levels can be observed (stages of the estrous cycle, pregnancy, lactation, stress etc.). A variety of inputs may thus result in elevated prolactin production. In the present paper, we will attempt to describe some of the neural factors which modulate the release of prolactin, focussing

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تاریخ انتشار 2007